RosettaCommons/RFD4-Proteina

Model

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What it is

A flow-matching generative model for designing proteins and biomolecular complexes, supporting sequence-structure co-design with motif and binding-site conditioning, partial diffusion, and reward-guided search. Inputs are CIF structures or YAML condition specifications.

Who it's for

Computational biologists and protein design researchers generating binders, enzymes, or motif scaffolds

How to use it

Install

make setup

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Help me install and set up RosettaCommons/RFD4-Proteina in my project. Follow its README: https://github.com/RosettaCommons/RFD4-Proteina. Explain each step and check it is safe before running anything.

Star curve

258From 0 to 258 stars between 25 Sept 2026 and 22 Oct 2026.

On the radar

Best place #33, on 22 Oct 2026. In the top 100 on 1 of the last 5 days.

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Records

Best place on RepoAlerts: #33, on 22 Oct 2026

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